Budde R
HNO. 1981 Mar;29(3):88-91.
We describe a new method for successful management of epistaxis in patients with hereditary hemorrhagic telangiectasias. By so doing, even pulmonary arteriovenous fistulas and gastrointestinal hemorrhages can be successfully managed. During a four year period, 14 patients were treated with an oral contraceptive preparation which combined a reduced dosage of estrogen and progesterone. With this therapy, 11 patients stopped bleeding while 3 responded with significant improvement. We believe that this effect on bleeding by the hormone therapy is a sign of an abnormal increase of specific hormone requirements in patients with Osler's disease.
我们描述了一种成功治疗遗传性出血性毛细血管扩张症患者鼻出血的新方法。通过这种方法，甚至肺动静脉瘘和胃肠道出血也能得到成功治疗。在四年期间，14例患者接受了一种口服避孕药制剂治疗，该制剂结合了减少剂量的雌激素和孕激素。通过这种治疗，11例患者止血，3例患者有显著改善。我们认为，激素疗法对出血的这种作用是奥斯勒病患者特定激素需求异常增加的一个迹象。
