Micheau P, Moreau J P, Chavoin J P, Chiotasso P, Costagliola M, Rumeau J L, Blasco A, Vigoni F
J Chir (Paris). 1981 Mar;118(3):197-205.
An experimental study was conducted in dogs to study the increase an vascular supply to an ischemic zone after transplantation of the greater omentum. The study design, applied in eleven dogs, is described, and the various technical details emphasized : staged vascular ligature of one paw, preparation of the omentum, and transplantation using microsurgical procedures. The circulatory deficiency, evaluated by comparison with the healthy or similarly ligatured opposite paw, is well-compensated by the omental transplant, and a new circulation is established. This is apparent on pathological examinations and arteriography. Isotopic angiography, by means of labelled erythrocytes, supplies proof that a vascular pool is effectively derived from the transplanted organ and that it reaches the distal region of the ischemic limb. The increase in blood supply obtained suggests the possibility of new clinical indications. Apart from omentoplasty, already widely used in plastic surgery, the omentum could perhaps also be effective in certain areas of cardiovascular surgery, especially in some cases of arteritis where the distal vascular bed is greatly reduced. Further experimental studies, such as these described, are necessary before using this technique in humans.
在犬类动物身上进行了一项实验研究,以探讨大网膜移植后缺血区域血管供应的增加情况。描述了应用于11只犬的研究设计,并强调了各种技术细节:对一只爪子进行分期血管结扎、大网膜的制备以及使用显微外科手术进行移植。通过与健康或类似结扎的对侧爪子进行比较来评估循环缺陷,大网膜移植能很好地补偿这种缺陷,并建立新的循环。这在病理检查和动脉造影中很明显。通过标记红细胞的同位素血管造影提供了证据,证明血管池有效地源自移植器官并到达缺血肢体的远端区域。所获得的血液供应增加表明了新的临床应用可能性。除了已经在整形手术中广泛使用的大网膜成形术外,大网膜在某些心血管手术领域可能也有效,特别是在一些远端血管床大幅减少的动脉炎病例中。在将该技术应用于人类之前,有必要进行如本文所述的进一步实验研究。