Roenigk H H, Caro W A
J Am Acad Dermatol. 1981 Mar;4(3):319-24. doi: 10.1016/s0190-9622(81)70032-x.
A 4-year follow-up study of 631 patients with psoriasis given 8-methoxypsoralen and UVA in the PUVA-48 cooperative study revealed only ten patients with skin cancer and eight patients with actinic keratosis. The skin cancer group averaged 14 years older than the group without lesions. The cumulative treatment ranged from 255 to 1,737 joules/cm2 at the time of development of skin cancer. The ratio of basal cell carcinoma to squamous cell carcinoma and the anatomic location of lesions generally follow the pattern of spontaneously developing lesions. Ionizing radiation was a significant risk factor, but previous arsenic exposure or skin cancer was not. Comparison with previous studies and lack of control population may indicate less risk of skin cancer following PUVA than previously suggested.
在PUVA - 48合作研究中，对631例接受8 - 甲氧基补骨脂素和紫外线A（PUVA）治疗的银屑病患者进行了为期4年的随访研究，结果显示仅有10例患皮肤癌，8例患光化性角化病。皮肤癌组患者的平均年龄比无病变组大14岁。在皮肤癌发生时，累积治疗剂量范围为255至1737焦耳/平方厘米。基底细胞癌与鳞状细胞癌的比例以及病变的解剖位置通常遵循自发发生病变的模式。电离辐射是一个显著的危险因素，但既往砷暴露或皮肤癌史并非如此。与先前研究的比较以及缺乏对照人群可能表明，PUVA治疗后皮肤癌的风险低于先前的推测。
