从黄体化大鼠卵巢制备对鸟苷三磷酸（GTP）敏感的腺苷酸环化酶。
Preparation of GTP sensitive adenylate cyclase from luteinized rat ovaries.
作者信息
Mcllroy P J, Ryan R J
出版信息
J Cyclic Nucleotide Res. 1980;6(5):379-89.
PMID:7217460
Abstract
Previous studies have shown that human chorionic gonadotropin stimulation of rat ovarian adenylate cyclase activity is enhanced but not augmented by GTP. Extraction of crude rat luteal membranes with 2M urea induced a GTP augmentation of hCG stimulation of adenylate cyclase activity of 3.5 fold. This augmentation of hormonal stimulation of adenylate cyclase activity by GTP was not accompanied by a decrease in hormone binding such as has been observed with other hormonally stimulated adenylate cyclase.
摘要
先前的研究表明，人绒毛膜促性腺激素对大鼠卵巢腺苷酸环化酶活性的刺激作用在GTP存在时增强但未增大。用2M尿素提取大鼠黄体粗膜可使GTP对人绒毛膜促性腺激素刺激腺苷酸环化酶活性的作用增大3.5倍。GTP对激素刺激腺苷酸环化酶活性的这种增大作用并不伴有激素结合的减少，而在其他激素刺激的腺苷酸环化酶中观察到了这种减少。
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