Imataka K, Seki A, Tomono S, Takahashi N, Fujii J
Jpn Heart J. 1981 Jan;22(1):127-33. doi: 10.1536/ihj.22.127.
Arterial dilatation distal to a stenosis has been known as poststenotic dilatation (PSD). This paper describes arterial constriction enough to produce PSD, time course of PSD, structural changes of the dilated segments and influence of hypertension on the development of PSD. These problems were studied in 2 experimental protocols. In protocol I, 87 carotid arteries of 45 rabbits were constricted by silver clip of 0.65 to 2.0 mm in diameter. The arterial diameter was measured at the sites both proximal and distal to the constriction after 3 days to 8 weeks. In protocol II, 22 carotid arteries of 12 rabbits with experimental one-or two-kidney Goldblatt hypertension were constricted and the development of PSD was compared with age matched controls. Remarkable PSD developed in arteries with moderate stenosis of 45 to 60% constriction. The degree of dilatation expressed as ratio of distal to proximal diameter reached about 1.5 at the end of the second week and remained unchanged thereafter. Destruction of the elastic fibers with intimal hyperplasia was observed in the dilated segments even at the early stages of the PSD. Both mild and severe stenosis failed to produce prominent PSD. In protocol II, the PSD averaged 1.18 +/- 0.05 (mean +/- SE) in hypertensive, and 1.32 +/- 0.03 in normotensive animals (p less than 0.05). The result suggests that chronic hypertension decreases the distensibility of the arteries.
狭窄远端的动脉扩张被称为狭窄后扩张（PSD）。本文描述了足以产生PSD的动脉收缩、PSD的时间进程、扩张段的结构变化以及高血压对PSD发展的影响。这些问题在2个实验方案中进行了研究。在方案I中，用直径0.65至2.0毫米的银夹对45只兔子的87条颈动脉进行收缩。在3天至8周后，测量收缩部位近端和远端的动脉直径。在方案II中，对12只患有实验性单肾或双肾Goldblatt高血压的兔子的22条颈动脉进行收缩，并将PSD的发展与年龄匹配的对照组进行比较。在狭窄程度为45%至60%的中度狭窄动脉中出现了明显的PSD。以远端与近端直径之比表示的扩张程度在第二周结束时达到约1.5，此后保持不变。即使在PSD的早期阶段，在扩张段也观察到弹性纤维破坏伴内膜增生。轻度和重度狭窄均未产生明显的PSD。在方案II中，高血压动物的PSD平均为1.18±0.05（平均值±标准误），正常血压动物为1.32±0.03（p<0.05）。结果表明，慢性高血压会降低动脉的扩张性。
