Lui K K, Enjoji M, Inokuchi K
Jpn J Surg. 1980 Dec;10(4):284-9. doi: 10.1007/BF02468789.
Two hundred and fifty-six tumors of carcinoma of the colon and rectum which had been surgically removed five or more years previously, and preserved in paraffin blocks, were examined for venous invasion using both routine hematoxylin and eosin (H-E) and by special stain for elastic fibers. In all these samples, 156 (61%) showed histological evidence of venous invasion and such was most frequently seen in the submucosa, followed by the subserosa or the perirectal fat. Since most of the involved veins showed marked destruction of the wall structure and were associated with total obstruction of the lumen, identification was difficult using the routine H-E strain. The frequency of venous invasion varied with the gross type of the tumor, the depth of penetration and the degree of differentiation, although there was no relation to size or to the site of the tumor. The incidence increased in cases of evident lymphatic permeation or lymph node involvement. The number of patients with venous invasion and a 5-year survival rate was significantly decreased, particularly in the Dukes' C cases. Thus, the determination of the extent of venous invasion using the elastic tissue stain is of definite prognostic value.
对256例五年或更久之前接受过手术切除并保存于石蜡块中的结肠直肠癌肿瘤标本，使用常规苏木精-伊红染色（H-E）和弹性纤维特殊染色法检查静脉侵犯情况。在所有这些样本中，156例（61%）显示有静脉侵犯的组织学证据，且最常见于黏膜下层，其次是浆膜下层或直肠周围脂肪组织。由于大多数受累静脉显示出明显的壁结构破坏并伴有管腔完全阻塞，使用常规H-E染色难以识别。静脉侵犯的频率随肿瘤大体类型、浸润深度和分化程度而变化，尽管与肿瘤大小或部位无关。在有明显淋巴管浸润或淋巴结受累的病例中，发生率增加。有静脉侵犯的患者数量和五年生存率显著降低，尤其是在Dukes' C期病例中。因此，使用弹性组织染色确定静脉侵犯范围具有明确的预后价值。
