Lack E E
J Thorac Cardiovasc Surg. 1981 May;81(5):741-6.
Two cases of massive thymic hyperplasia (MTH) are reported in boys 11 and 14 years of age. Each was detected on routine chest roentgenogram as a large anterior mediastinal mass. Total thymectomy was successfully performed and the two patients were alive and well 9 and 17 years later. The thymectomy specimens weighed 324 and 490 gm, respectively, and had uniform histologic anatomy without lymphoid nodules. Morphometric study documented the massive increase in thymic parenchyma (i.e., true hyperplasia) with retention of a normal proportion of connective tissue expected for age. Since thymic size and structure normally become modified with age, it is essential to consult standard reference data when evaluating hypertrophy and hyperplasia. Gross and histologic features distinguishing MTH from childhood thymoma are discussed.
报告了两例11岁和14岁男孩的巨大胸腺增生（MTH）病例。两例均在常规胸部X线检查时被发现为前纵隔巨大肿块。均成功实施了全胸腺切除术，9年和17年后两名患者均存活且状况良好。胸腺切除标本分别重324克和490克，组织学结构均匀，无淋巴小结。形态计量学研究证实胸腺实质大量增加（即真正的增生），且结缔组织比例保持在该年龄预期的正常范围内。由于胸腺大小和结构通常会随年龄发生改变，因此在评估肥大和增生时参考标准参考数据至关重要。文中讨论了区分MTH与儿童胸腺瘤的大体和组织学特征。
