Tabernero Romo J M, Rodriguez Commes J L, de Manueles J, González Macías S, Bondía A, Acosta A, Marcías Núñez J F, de Castro del Pozo S
Med Clin (Barc). 1981 Jan 25;76(2):61-4.
The subjects of this study were 18 patients with essential or secondary epilepsy under treatment with anticonvulsant drugs (hydantoins and phenobarbital) for periods of time varying between 8 months and 22 years. In all of them the serum levels of calcium, phosphorus, alkaline phosphatase, and the renal tubular capacity to acidify the urine were measured. Mean serum calcium and phosphorus levels were normal, while alkaline phosphatase was significantly elevated (p less than 0.0005). The renal threshold for bicarbonate was lowered to a mean of 23.01 +/- 2.86 (p less than 0.01). Distal tubular function was normal in all cases. When the patients are divided into two groups according to the duration of treatment (more or less than 100 months), the group with longest therapy shows an elevation of alkaline phosphatase (p less than 0.0005), a lowering of serum calcium (p less than 0.025) and a reduction of the renal threshold for bicarbonate (p less than 0.005) when compared to the group with shortest therapy.
本研究的对象为18例原发性或继发性癫痫患者，他们正在接受抗惊厥药物（乙内酰脲类和苯巴比妥）治疗，治疗时间在8个月至22年之间。对所有患者均测定了血清钙、磷、碱性磷酸酶水平以及肾小管酸化尿液的能力。血清钙和磷的平均水平正常，而碱性磷酸酶显著升高（p<0.0005）。碳酸氢盐的肾阈值降至平均23.01±2.86（p<0.01）。所有病例的远端肾小管功能均正常。根据治疗时间（100个月以上或以下）将患者分为两组，与治疗时间最短的组相比，治疗时间最长的组碱性磷酸酶升高（p<0.0005），血清钙降低（p<0.025），碳酸氢盐的肾阈值降低（p<0.005）。
