Glycoproteins and glycopeptides in the chromaffin granule membrane.

The glycoproteins and glycopeptides of adrenal chromaffin granule membranes have been analyzed by gel filtration, electrophoresis, and amino acid analysis. It has been found that almost all of the polypeptides present in the membrane are glycoproteins. Indeed, most of these possess sugar specificities which permit binding to concanavalin A-Sepharose. A new set of low-molecular-weight glycopeptides was found. There is an inverse correlation between carbohydrate content and polypeptide molecular weight.