Ghirlanda G, Greco A V, Altomonte L, Manna R, Pala M A, Rebuzzi A G
Minerva Med. 1981 Apr 7;72(14):893-5.
Irreversible lactic acidosis occurred in two phenformin-treated diabetics. In the first case, blood creatinine was 3 mg % ml, arterial blood pH was 7,12 and ketostix was negative; in the second case, blood creatinine was 1,3 mg% ml, arterial blood pH was 7,22 and ketostix was negative. Diabetic patients to be treated with phenformin must always be carefully selected and this treatment should be reserved for cases where there is a precise indication. Lactic acidosis may occur even in the presence of almost normal serum creatinine concentrations.
两名接受苯乙双胍治疗的糖尿病患者发生了不可逆性乳酸性酸中毒。在第一例中，血肌酐为3mg%ml，动脉血pH值为7.12，尿酮试纸检测为阴性；在第二例中，血肌酐为1.3mg%ml，动脉血pH值为7.22，尿酮试纸检测为阴性。接受苯乙双胍治疗的糖尿病患者必须始终经过仔细挑选，这种治疗应仅用于有明确指征的病例。即使血清肌酐浓度几乎正常，也可能发生乳酸性酸中毒。
