Agnati L F, Benfenati F, Capelli M, Cocchi V, D'Errico A, Bernardi P
Neurosci Lett. 1981 Feb 6;21(3):333-8. doi: 10.1016/0304-3940(81)90226-3.
The effects of methysergide (1 mg, p.o.), clonidine (50 micrograms, i.m.) and methysergide plus clonidine on growth hormone (GH) and prolactin (PRL) secretion in 8 normal male volunteers have been studied. Both methysergide and clonidine were found to enhance GH and to lower PRL plasma levels. The effects of methysergide are explained on the basis of a preferential action of methysergide metabolites on dopamine receptors, whereas the effects of clonidine are attributed to a stimulatory action on adrenaline receptors. The combined treatment methysergide plus clonidine resulted in a potentiation of the effects caused by the drugs when administered alone.
研究了麦角新碱（口服1毫克）、可乐定（肌肉注射50微克）以及麦角新碱加可乐定对8名正常男性志愿者生长激素（GH）和催乳素（PRL）分泌的影响。发现麦角新碱和可乐定都能提高GH水平并降低PRL血浆水平。麦角新碱的作用是基于其代谢产物对多巴胺受体的优先作用来解释的，而可乐定的作用则归因于对肾上腺素受体的刺激作用。麦角新碱加可乐定的联合治疗导致药物单独使用时所产生的效应增强。
