Chung C K, Stryker J A, Ward S P, Nahhas W A, Mortel R
Obstet Gynecol. 1981 May;57(5):636-42.
A histologic grading system based on tumor differentiation was applied in a study of 122 patients with stage IB and IIA squamous cell carcinoma of the uterine cervix. In general, the more dedifferentiated the primary tumor, the more bulky the primary lesion and the higher the incidence of pelvic node metastasis. Following treatment, patients with undifferentiated tumors had a higher incidence of tumor recurrence a lower 2-year survival rate than those with well or moderately differentiated lesions. These findings suggest that histologic grading is an important adjunct to the clinical evaluation of cervical cancer.
在一项针对122例子宫颈IB期和IIA期鳞状细胞癌患者的研究中，应用了基于肿瘤分化的组织学分级系统。一般来说，原发性肿瘤的分化程度越低，原发性病变越大，盆腔淋巴结转移的发生率越高。治疗后，未分化肿瘤患者的肿瘤复发率较高，2年生存率低于高分化或中分化病变患者。这些发现表明，组织学分级是宫颈癌临床评估的重要辅助手段。
