Bacourt F, Danel O, Conseiller C, Frija G, Marchand M
Nouv Presse Med. 1981 Apr 11;10(16):1317-9.
In patients with cardiac failure, coronary disease or arterial hypertension, clamping of the aorta results in increased filling pressure of the left ventricle which may produce or increase subendocardial ischaemia with consequent aggravation of the ventricular insufficiency. And the higher the clamping the greater the risk. This vicious circle can be broken by sodium nitroprusside, which has potent and reversible vasodilator properties. The drug is indicated whenever the left ventricular filling pressure rises above 5 mmHg. These considerations are illustrated by the descriptions of a case where sodium nitroprusside ensured blood circulation in the lower limbs and intra-abdominal organs after clamping of the aorta above the coeliac artery in a high risk cardiac patient.
在心力衰竭、冠心病或动脉高血压患者中，夹闭主动脉会导致左心室充盈压升高，这可能会产生或加重心内膜下缺血，进而加重心室功能不全。夹闭程度越高，风险越大。硝普钠可以打破这个恶性循环，它具有强效且可逆的血管舒张特性。只要左心室充盈压升至5 mmHg以上，就应使用该药。一名高危心脏病患者在腹腔动脉上方夹闭主动脉后，硝普钠确保了其下肢和腹腔内器官的血液循环，这一病例描述说明了上述观点。
