Bakouche P, Vedrenne C, Beaumont V, Chaouat D, Reignier A, Nick J
Rev Neurol (Paris). 1980;136(8-9):509-19.
Pathological examination in a patient who developed an ischemic cerebrovascular accident while taking an oral contraceptive demonstrated widespread lesions in the right and left carotid regions. Histological examination revealed the presence of an obliterating thromboangiitis in the arterial walls, with subendothelial fibrosis of the intima, arterial thrombosis, and a marked giant cell reaction where the lesions were in contact with the internal elastic layer. Immunological and biological anomalies confirmed the inflammatory nature of the lesion with the presence of anti-ethinyl estradiol antibodies in the serum and circulating blood immune complexes. These biological and histological results suggest the immunological nature of the mechanism of origin of the cerebrovascular accident in this case.
一名在服用口服避孕药期间发生缺血性脑血管意外的患者的病理检查显示，左右颈动脉区域存在广泛病变。组织学检查发现动脉壁有闭塞性血栓性血管炎，内膜有内皮细胞下纤维化、动脉血栓形成，且病变与内弹性层接触处有明显的巨细胞反应。免疫学和生物学异常证实了病变的炎症性质，血清中存在抗乙炔雌二醇抗体以及循环血液免疫复合物。这些生物学和组织学结果表明，该病例中脑血管意外的发病机制具有免疫性质。
