Schneider J
Schweiz Med Wochenschr. 1981 Mar 14;111(11):366-74.
This quantitative histological study of the conduction system comprises 57 patients showing electrocardiographically documented conduction disturbances. In the sinu-atrial node of all patients with sick sinus syndrome the ratio of specific cells to connective tissue shows a shift in favour of connective tissue. In most patients with permanent complete atrio-ventricular block, we found a lesion destroying three quarters of the fibres at one level at least of the av-node or the main bundle. These criteria are used to investigate the conduction system of patients dying suddenly and unexpectedly. A ratio of specific cells to connective tissue below 0.2 in the sinu-atrial node is highly suggestive of nodal dysfunction. A lesion of the av-node or the main bundle comprising three quarters of the whole structure is nearly always accompanied by av-block. If such a lesion in the conduction system is the only pathological autopsy finding, the cause of death is most probably cardiac arrest due to this lesion.
这项关于传导系统的定量组织学研究纳入了57例有心电图记录的传导障碍患者。在所有病态窦房结综合征患者的窦房结中，特定细胞与结缔组织的比例显示出有利于结缔组织的变化。在大多数永久性完全房室传导阻滞患者中，我们发现至少在房室结或主束的一个层面上有病变破坏了四分之三的纤维。这些标准用于研究突然意外死亡患者的传导系统。窦房结中特定细胞与结缔组织的比例低于0.2高度提示结功能障碍。房室结或主束的病变占整个结构的四分之三几乎总是伴有房室传导阻滞。如果传导系统中的这种病变是尸检唯一的病理发现，死亡原因很可能是由于该病变导致的心脏骤停。
