Millicovsky G, Johnston M C
Science. 1981 May 8;212(4495):671-2. doi: 10.1126/science.7221553.
The A/J mouse has been used to study the teratogenic affects of phenytoin. The developmental abnormalities produced in offspring of this model are similar to some of the malformations observed in cases of human "fetal hydantoin syndrome." Placing pregnant A/J mice in a hyperoxic chamber after phenytoin injection greatly reduces the incidence of phenytoin-induced cleft lip and palate. These results suggest that phenytoin may affect embryonic development indirectly by altering maternal physiology. This maternally mediated mechanism, and the protection against it afforded by hyperoxia, has general implications for the effects of maternal toxicity on teratogenesis.
A/J小鼠已被用于研究苯妥英的致畸作用。该模型后代出现的发育异常与人类“胎儿乙内酰脲综合征”病例中观察到的一些畸形相似。在注射苯妥英后将怀孕的A/J小鼠置于高氧舱中，可大大降低苯妥英诱导的唇腭裂发生率。这些结果表明，苯妥英可能通过改变母体生理间接影响胚胎发育。这种母体介导的机制以及高氧对其的保护作用，对母体毒性对致畸作用的影响具有普遍意义。
