Röhme D, Thorburn D
Somatic Cell Genet. 1981 Jan;7(1):43-57. doi: 10.1007/BF01544747.
Cell fusion experiments were made on ten cell lines representing seven mammalian species, using inactivated Sendai virus. The extent of fusion was determined microscopically and tabulated as frequencies of cell with different numbers of nuclei. Expected distributions were derived theoretically under certain assumptions concerning the fusion process. A random model was assumed according to which the tendency to fuse depends only on the cell size, expressed as the number of nuclei present in the cell. Three distributions were derived, which were referred to as the simple, additive, and multiplicative models. The additive model pertained to fusions made in cell suspensions and the multiplicative one mainly to fusions in fibroblast monolayers.
使用灭活的仙台病毒对代表七种哺乳动物物种的十种细胞系进行了细胞融合实验。通过显微镜确定融合程度，并将其列为具有不同核数的细胞频率。在关于融合过程的某些假设下，从理论上推导了预期分布。假设了一个随机模型，根据该模型，融合倾向仅取决于细胞大小，以细胞中存在的核数表示。推导了三种分布，分别称为简单模型、加法模型和乘法模型。加法模型适用于细胞悬液中的融合，而乘法模型主要适用于成纤维细胞单层中的融合。
