Murthy R C, Srivastava R S, Chandra S V
Toxicol Lett. 1981 Jan;7(3):217-20. doi: 10.1016/0378-4274(81)90071-0.
Rats were exposed to manganese (Mn) (6 mg/kg) daily for 30 days. The content of ceruloplasmin decreased significantly by 19.5% while copper (Cu) content was reduced by 27.8% in the serum of Mn-treated animals. These alterations were associated with a marked increase in the Cu content of liver and brain. The significant decrease in serum Cu and ceruloplasmin may serve as useful parameters for early diagnosis of Mn poisoning.
大鼠每天暴露于锰（Mn）（6毫克/千克）中，持续30天。在经锰处理的动物血清中，血浆铜蓝蛋白含量显著下降了19.5%，而铜（Cu）含量降低了27.8%。这些变化与肝脏和大脑中铜含量的显著增加有关。血清铜和血浆铜蓝蛋白的显著下降可能作为锰中毒早期诊断的有用参数。
