胆酸生物前体的合成II。
Synthesis of biological precursors of cholic acid II.
作者信息
Dayal B, Tint G S, Batta A K, Shefer S, Salen G
出版信息
Steroids. 1981 Feb;37(2):205-11. doi: 10.1016/s0039-128x(81)80018-9.
This paper describes the partial syntheses of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestan-26-al, 7 alpha, 12 alpha, 26-trihydroxy-5 beta-cholestan-3-one and 7 alpha, 12 alpha-dihydroxy-3-oxo-5 beta-cholestan-26-al via Ag2CO3/Celite oxidation of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 26-tetrol. These bile alcohols were resolved by analytical and preparative TLC, characterized by gas-liquid chromatography and mass spectrometry. These compounds will be useful to delineate further the mechanism of oxidation of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 25-tetrol on the pathway to cholic acid.
本文描述了通过5β-胆甾烷-3α，7α，12α，26-四醇的碳酸银/硅藻土氧化反应部分合成3α，7α，12α-三羟基-5β-胆甾烷-26-醛、7α，12α，26-三羟基-5β-胆甾烷-3-酮和7α，12α-二羟基-3-氧代-5β-胆甾烷-26-醛。这些胆汁醇通过分析型和制备型薄层色谱法进行拆分，通过气液色谱法和质谱法进行表征。这些化合物将有助于进一步阐明5β-胆甾烷-3α，7α，12α，25-四醇在通往胆酸的途径上的氧化机制。
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