Stöber U, Aeikens B
Urol Int. 1980;35(6):395-403. doi: 10.1159/000280356.
After a complete destruction of the ureter, renal function recovers more completely after diversion of the urine by splints than by ureterocystoneostomy. After a longer period of obstruction and successive restoration of urinary diversion by ureterocystoneostomy a relative increase in pressure of the ureter continues. This is the result of a functional obstruction, caused by disintegration of the muscle cells by connective tissue. The proliferation of connective tissue is probably induced and maintained by extravasation of urine into the layers of the ureter and that after abolition of the special function of the tunica mucosa. The defects of the mucosa are probably caused by metabolic disturbance after a pressure-induced decrease of blood supply.
输尿管完全破坏后,通过夹板进行尿液改道比输尿管膀胱吻合术能使肾功能更完全地恢复。在较长时间梗阻并通过输尿管膀胱吻合术相继恢复尿液引流后,输尿管压力会持续相对升高。这是由于结缔组织使肌肉细胞解体导致的功能性梗阻所致。结缔组织的增生可能是由尿液渗入输尿管各层以及黏膜层特殊功能丧失后所诱发并维持的。黏膜缺损可能是压力导致血液供应减少后代谢紊乱引起的。