Gelman M L, Lichtenstein N S
Urology. 1981 Apr;17(4):323-7. doi: 10.1016/0090-4295(81)90255-7.
Two cases are reported of combined renal and hepatic failure following exposure to halothane anesthesia. Both patients presented with postoperative fever and rapidly deteriorating liver and kidney function. Both required peritoneal dialysis. Both patients died, and in both cases this was the second exposure to halothane. The pathologic features of the 2 cases were similar in that the liver changes were typical of those seen with halothane hepatitis and the renal lesion was similar to that of methoxyflurane nephritis. This is, to our knowledge, the third report of renal failure occurring after halothane anesthesia. Possible mechanisms regarding its toxicity are discussed.
报告了两例在接受氟烷麻醉后出现肝肾联合衰竭的病例。两名患者均表现为术后发热，肝功能和肾功能迅速恶化。两人均需要进行腹膜透析。两名患者均死亡，且均为第二次接触氟烷。这两例病例的病理特征相似，肝脏改变为氟烷性肝炎的典型表现，肾脏病变类似于甲氧氟烷性肾炎。据我们所知，这是关于氟烷麻醉后发生肾衰竭的第三篇报告。文中讨论了其毒性的可能机制。
