[Combination chemotherapy in the adjuvant treatment of disseminated breast cancer].

The results of clinical studies are presented on the combined chemotherapy in spread breast cancer, conducted according to the following three schedules: 1. thiophosphamide, carminomycin, vincristine, ftorafur, prednisolone, 2. diiodobenzoTEPA, carminomycin, vincristine, ftorafur, prednisolone, 3. methotrexate, cyclophosphane, vincristine, ftorafur, prednisolone. The combined chemotherapy in the complex treatment of 91 patients with spread breast cancer was found to be effective in 33-40% of cases. Primary tumors of the mammary gland and metastases in soft tissues, lymph nodes were mostly sensitive to the combined chemotherapy, metastases in bones and visceral organs--less sensitive. Schedules 2 and 3 proved to be the least toxic ones.