Witt S
Z Gesamte Inn Med. 1981 Jan 15;36(2):38-42.
Diabetes is a heterogeneous disease, and its pathogenesis and etiology are still largely unknown. Recent studies have brought new knowledge showing that HLA antigens and diabetes mellitus are related. It has been found that the relative risk of juvenile onset diabetes requiring insulin treatment is greater for persons who are HLA-A1, A2, B8, BW15, BW40, CW3, DW3, DW4, DRW3 and DRW4 positive. The relative risk of the disease is additive in persons who have two of the above mentioned HLA-B alleles. Some HLA antigens (HLA-B7, DW2, DRW2, A11) are associated with a significantly lower risk of the disease and probably have a "protective" character. Maturity onset diabetes (MOD) and maturity onset diabetes not requiring insulin treatment (MODY) are not related to the HLA system. This means that MOD is completely distinct from JOD with different symptoms, course and etiopathogenesis.
糖尿病是一种异质性疾病，其发病机制和病因在很大程度上仍不明确。最近的研究带来了新的知识，表明人类白细胞抗原（HLA）与糖尿病有关。已发现，HLA - A1、A2、B8、BW15、BW40、CW3、DW3、DW4、DRW3和DRW4呈阳性的人，患需胰岛素治疗的青少年发病型糖尿病的相对风险更高。对于具有上述两种HLA - B等位基因的人，该疾病的相对风险是累加的。一些HLA抗原（HLA - B7、DW2、DRW2、A11）与该疾病的风险显著降低相关，可能具有“保护”特性。成年发病型糖尿病（MOD）和无需胰岛素治疗的成年发病型糖尿病（MODY）与HLA系统无关。这意味着MOD与青少年发病型糖尿病（JOD）完全不同，具有不同的症状、病程和病因发病机制。
