Gershoff S N, McGandy R B
Am J Clin Nutr. 1981 Apr;34(4):483-9. doi: 10.1093/ajcn/34.4.483.
This report describes studies in which diets have been developed which when fed to rats commonly result in the formation of primary urinary bladder calculi. The bladder walls of most of these rats but not those without urinary stones were grossly hypertrophied. Microscopic examinations in one of the studies indicated that about a quarter of the bladders containing stones showed histological changes consistent with those characterized as grade I to II transitional cell carcinomas. In all cases animals showing these histological abnormalities consumed vitamin A-deficient diets in which the carbohydrate was supplied mostly by lactose.
本报告描述了一些研究，其中所制定的饮食喂给大鼠后通常会导致原发性膀胱结石的形成。大多数出现这种情况的大鼠的膀胱壁明显肥厚，但没有尿路结石的大鼠膀胱壁则不然。其中一项研究的显微镜检查表明，约四分之一有结石的膀胱显示出与I至II级移行细胞癌特征一致的组织学变化。在所有病例中，出现这些组织学异常的动物均食用了维生素A缺乏的饮食，其中碳水化合物主要由乳糖提供。
