硝普钠对正常血压和高血压妊娠绵羊血流动力学的影响

Nitroprusside-induced hemodynamic alterations in normotensive and hypertensive pregnant sheep.

作者信息

Lieb S M, Zugaib M, Nuwayhid B, Tabsh K, Erkkola R, Ushioda E, Brinkman C R, Assali N S

出版信息

Am J Obstet Gynecol. 1981 Apr 15;139(8):925-31. doi: 10.1016/0002-9378(81)90960-1.

Abstract

It has been suggested that sodium nitroprusside, a potent vasodilator, be used in the management of an acute hypertensive crisis during pregnancy. The present study was designed to evaluate the hemodynamic effects of this agent in the same group of chronically instrumented, unanesthetized pregnant sheep during two experimental periods: (a) normotension with intact kidneys, and (b) one-kidney hypertension. The results demonstrate that (1) nitroprusside is a potent vasodilator which lowers mean arterial pressure; (2) nitroprusside-induced tachycardia was greater in the hypertensive animal; (3) uterine blood flow decreased with the development of hypertension; (4) the hypertensive-induced reduction in uterine blood flow was increased by the infusion of nitroprusside.

摘要

有人建议使用强效血管扩张剂硝普钠来治疗妊娠期急性高血压危象。本研究旨在评估该药在同一组长期植入仪器、未麻醉的妊娠绵羊两个实验阶段的血流动力学效应：（a）肾脏完整时的正常血压阶段，以及（b）单肾高血压阶段。结果表明：（1）硝普钠是一种强效血管扩张剂，可降低平均动脉压；（2）硝普钠诱发的心动过速在高血压动物中更明显；（3）随着高血压的发展，子宫血流量减少；（4）输注硝普钠会增加高血压引起的子宫血流量减少。