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在低动力性和贫血性缺氧状态下血小板和白细胞在静脉中的隔离与边缘化:对临床术后静脉血栓形成的潜在意义

The sequestration and margination of platelets and leucocytes in veins during conditions of hypokinetic and anaemic hypoxia: potential significance in clinical postoperative venous thrombosis.

作者信息

Malone P C, Morris C J

出版信息

J Pathol. 1978 Jul;125(3):119-29. doi: 10.1002/path.1711250302.

DOI:10.1002/path.1711250302
PMID:722394
Abstract

Lesions apparently similar to the white part of natural and experimental thrombi were found in the veins of animals starved of oxygen by "hypokinetic" and "anaemic" means: in contrast to this, no comparable lesions were seen in animals exposed to "arterial" hypoxia. The interpretation of these observations, and their probable relevance to the conditions in which postoperative venous thrombi develop, is discussed.

摘要

通过“运动不足”和“贫血”方式造成缺氧的动物静脉中,发现了与自然血栓和实验性血栓白色部分明显相似的病变:与此形成对比的是,在遭受“动脉性”缺氧的动物中未观察到类似病变。本文讨论了这些观察结果的解释及其与术后静脉血栓形成条件的可能关联。

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The sequestration and margination of platelets and leucocytes in veins during conditions of hypokinetic and anaemic hypoxia: potential significance in clinical postoperative venous thrombosis.在低动力性和贫血性缺氧状态下血小板和白细胞在静脉中的隔离与边缘化:对临床术后静脉血栓形成的潜在意义
J Pathol. 1978 Jul;125(3):119-29. doi: 10.1002/path.1711250302.
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The behaviour of platelets and leucocytes in conditions of hypokinetic and anaemic hypoxia, contrasted with the absence of such behaviour in arterial hypoxia [proceedings].血小板和白细胞在低动力性和贫血性缺氧条件下的行为,与动脉性缺氧时不存在这种行为形成对比[会议论文集]
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Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia.由早期生长反应因子-1(Egr-1)驱动的组织因子转录是小鼠低氧性肺纤维蛋白沉积的关键机制。
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Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation.
单核细胞和组织因子在缺氧小鼠模型中促进血栓形成。
J Clin Invest. 1997 Apr 1;99(7):1729-38. doi: 10.1172/JCI119337.