Berry C L, Slocombe G W, Freeman P
J Pathol. 1978 Aug;125(4):193-200. doi: 10.1002/path.1711250404.
Intraperitoneal injection of mercuric chloride in the rat was used to study the effect of tubular injury on renal growth in intact and in unilaterally nephrectomised animals. If a reduction in the size of the tubular cell pool was effected, hypertrophy of surviving cells, rather than hyperplasia, would be the dominant response in treated animals. The remaining kidney in animals which had undergone nephrectomy showed hyperplasia without hypertrophy. However, unilaterally nephrectomised animals treated with mercuric chloride showed evidence of hypertrophy only, with no hyperplasia.
在大鼠体内进行腹腔注射氯化汞，以研究肾小管损伤对完整动物和单侧肾切除动物肾脏生长的影响。如果肾小管细胞池的大小减小，那么在接受治疗的动物中，存活细胞的肥大而非增生将是主要反应。接受肾切除的动物的剩余肾脏表现为增生而非肥大。然而，用氯化汞治疗的单侧肾切除动物仅表现出肥大迹象，没有增生。
