Feldman W E, Nelson J D, Stanberry L R
J Pediatr. 1978 Dec;93(6):1029-33. doi: 10.1016/s0022-3476(78)81251-7.
Nafcillin (150 mg/kg/day, divided every six hours) was administered intravenously to 46 patients ranging from 5 to 163 months of age with suspected or proved bacterial infections. Thirteen of 15 patients with bacteriologically proved infection responded to nafcillin. Two patients with cellulitis due to Escherichia coli or to Hemophilus influenzae type b did not improve with nafcillin therapy. A mean serum nafcillin concentration of 48 microgram/ml was observed 30 minutes after a dose of 37.5 mg/kg. The mean serum half-life was 0.76 hours. There was no significant relation between age and serum half-life, volume of distribution, or plasma clearance rate. Two patients developed neutropenia and six other patients developed an eosinophilia greater than 400/mm3 while receiving nafcillin. No significant toxic effect of nafcillin on liver or renal function was observed. One patient had phlebitis. There was a significant correlation between nfacillin concentrations and serum inhibitory and bactericidal titers (P less than 0.001). Results from this study indicate that nafcillin is a safe and effective antibiotic for the treatment of infections due to susceptible bacteria in the dosage tested.
对46例年龄在5至163个月之间、疑似或确诊细菌感染的患者静脉注射萘夫西林（150mg/kg/天，每6小时给药一次）。15例细菌学确诊感染的患者中有13例对萘夫西林有反应。2例因大肠杆菌或b型流感嗜血杆菌引起蜂窝织炎的患者，萘夫西林治疗无效。给予37.5mg/kg剂量后30分钟，观察到平均血清萘夫西林浓度为48μg/ml。平均血清半衰期为0.76小时。年龄与血清半衰期、分布容积或血浆清除率之间无显著相关性。2例患者出现中性粒细胞减少，6例其他患者在接受萘夫西林治疗时出现嗜酸性粒细胞增多，超过400/mm³。未观察到萘夫西林对肝功能或肾功能有明显毒性作用。1例患者发生静脉炎。萘夫西林浓度与血清抑菌和杀菌效价之间存在显著相关性（P<0.001）。本研究结果表明，在所测试的剂量下，萘夫西林是一种治疗易感细菌感染的安全有效的抗生素。
