Gavin M, Blair S
Arch Otolaryngol. 1981 Jun;107(6):372-6. doi: 10.1001/archotol.1981.00790420046010.
The vestibulo-ocular reflex (VOR) in the macaque was tested by a modified Bárány spinning test before and after subcutaneous administration of 1 mg/kg of picrotoxin. The drug caused a decrease in the nystagmus time constant to a value near that of the cupula and a decrease in mystagmus asymmetry. Picrotoxin prevented diazepam from increasing the time constant of vestibular nystagmus. Furthermore, picrotoxin reduced the nystagmus time constant after vermisectomy, a lesion that increases the nystagmus time constant and prevents some VOR modifications. Because picrotoxin and diazepam interact antagonistically in the gamma-aminobutyric acid (GABA) neurotransmitter system, these results show a role of GABA in the neural network that transforms a short cupula time constant into a longer nystagmus time constant.
在皮下注射1mg/kg印防己毒素前后，通过改良的巴兰尼旋转试验对猕猴的前庭眼反射（VOR）进行了测试。该药物使眼震时间常数降低至接近壶腹嵴的值，并使眼震不对称性降低。印防己毒素阻止地西泮增加前庭眼震的时间常数。此外，在切除蚓部后，印防己毒素降低了眼震时间常数，切除蚓部会增加眼震时间常数并阻止一些VOR的改变。由于印防己毒素和地西泮在γ-氨基丁酸（GABA）神经递质系统中相互拮抗作用，这些结果表明GABA在将短的壶腹嵴时间常数转变为长的眼震时间常数的神经网络中发挥作用。
