Glamkowski E J, Reitano P A, Woodward D L
J Pharm Sci. 1978 Dec;67(12):1773-4. doi: 10.1002/jps.2600671240.
A series of 3-substituted 1-[4-(2-indol-3-ylethyl)piperazinyl]ureas was synthesized and screened for antihypertensive activity in spontaneously hypertensive rats. Two compounds with aryl urea substituents were very potent and lowered blood pressure 55 mm or more at oral doses of 100 mg/kg. However, both compounds failed to produce a cardiovascular response in the normotensive dog.
