Halata Z
Bibl Anat. 1981(19):210-35.
The postnatal development of sensory nerve endings has been studied in the skin of the planum nasale of the cat. The Merkel nerve endings develop in the prenatal period; after birth some redundant axons perish. Up to the third postnatal day, sporadic Merkel cells and nerve terminals still can be observed in the stratum papillare of the dermis. The free nerve endings in the dermis appear before birth. In the postnatal period the nerve fibres as well as the nerve endings ramify. A few of them come into contact with the stratum basale of the epidermis, others may perish. Most of these nerve endings are located in the stratum papillare of the dermis. The simple encapsulated corpuscles with an inner core develop after birth. In the depth of the dermis, the corpuscles are arranged mainly in groups, in the stratum papillare, however, they are more isolated. The development of those corpuscles, located in the depth of the dermis, already begins before birth and finishes mostly about the 39th postnatal day. The development of the corpuscles in the stratum papillare starts later and ends between the 3rd and 4th month. The nerve terminal of the corpuscle changes only slightly during development. It elongates, becomes thicker, and the number of mitochondria increases. During all stages it sends cytoplasmic spines in between the lamellar system of the inner core. The inner core is formed by cytoplasmic lamellae of the peripheric glial cells. In the course of development the number of cytoplasmic lamellae increases, they become thinner and gradually each one will be covered by a basal lamina. A mature corpuscle possesses an inner core with one or two longitudinal clefts. These clefts occur more frequently in corpuscles with complete capsules. The connective tissue cells primarily form a primitive capsule around the inner core. During development the layers of the capsule increase in number. Mature corpuscles have a one- to four-layered capsule. The capsular cells are then ensheathed by a basal lamina.
已对猫鼻平面皮肤中感觉神经末梢的产后发育进行了研究。默克尔神经末梢在产前发育；出生后一些多余的轴突会消亡。在出生后第三天之前，仍可在真皮乳头层观察到散在的默克尔细胞和神经末梢。真皮中的游离神经末梢在出生前就已出现。在产后阶段，神经纤维以及神经末梢会分支。其中一些与表皮基底层接触，其他的可能会消亡。这些神经末梢大多位于真皮乳头层。具有内核的简单被囊小体在出生后发育。在真皮深层，小体主要成群排列，然而在乳头层，它们则较为孤立。位于真皮深层的那些小体的发育在出生前就已开始，大多在出生后第39天左右完成。乳头层中小体的发育开始较晚，在第3至4个月之间结束。小体的神经末梢在发育过程中变化不大。它会伸长、变粗，线粒体数量增加。在所有阶段，它都会在内核的板层系统之间发出细胞质棘。内核由外周神经胶质细胞的细胞质板层形成。在发育过程中，细胞质板层的数量增加，它们变薄，并且逐渐每个都会被基膜覆盖。一个成熟的小体具有一个带有一或两个纵向裂隙的内核。这些裂隙在具有完整被囊的小体中更常见。结缔组织细胞主要在内核周围形成一个原始被囊。在发育过程中，被囊的层数增加。成熟的小体有一层到四层的被囊。然后被囊细胞被基膜包裹。
