Pinaud M, Rochedreux A, Souron R, Nicolas F
Br J Anaesth. 1981 Apr;53(4):393-7. doi: 10.1093/bja/53.4.393.
Patients with chronic ischaemic heart disease and a history of myocardial infarction or who present with exertional or spontaneous angina suffer a decrease in left ventricular pump function during recovery from anaesthesia and in the period immediately after operation. This decrease is reflected in an increase in pulmonary capillary wedge pressure and in a decrease in stroke volume and cardiac output. Two groups of 10 such patients, clinically and haemodynamically comparable in the preoperative period, were studied: 10 patients received balanced anaesthesia, and 10 neuroleptanalgesia. The disturbance in left ventricular function was less pronounced with neuroleptanalgesia. A significant difference was noted between the groups with regard to pulmonary capillary wedge pressure during recovery from anaesthesia (balanced anaesthesia 15.8 +/- 4.4 mm Hg; neuroleptanalgesia 10.7 +/- 4.4 mm Hg; P less than 0.02). There was a relationship between type of anaesthesia and pulmonary capillary wedge pressure variations (P less than 0.01).
患有慢性缺血性心脏病且有心肌梗死病史或表现为劳累性或自发性心绞痛的患者，在麻醉恢复期间及术后即刻左心室泵功能会下降。这种下降表现为肺毛细血管楔压升高，以及每搏量和心输出量降低。研究了两组各10例此类患者，他们在术前临床和血流动力学方面具有可比性：10例患者接受平衡麻醉，10例接受神经安定镇痛麻醉。神经安定镇痛麻醉时左心室功能的紊乱不那么明显。两组在麻醉恢复期间的肺毛细血管楔压存在显著差异（平衡麻醉15.8±4.4 mmHg；神经安定镇痛麻醉10.7±4.4 mmHg；P<0.02）。麻醉类型与肺毛细血管楔压变化之间存在关联（P<0.01）。
