King D S
Biol Psychiatry. 1981 Jan;16(1):3-19.
Clinical ecologists report that exposure to allergens can induce cognitive and emotional symptoms as well as somatic symptoms in susceptible individuals, but controlled tests are meager. In a test of the hypothesis that sublingual exposure to allergens would produce cognitive-emotional symptoms in allergy patients, double-blind provocative testing was conducted at an allergy clinic; 30 allergy patients complaining of at least one psychological symptom were selected. Self-report, heart-rate, and several mood and psychological performance measures were obtained. MMPI scores indicated a pathological sample. Reported cognitive-emotional symptoms were greater for allergens than for placebos (p = 0.001), while placebo symptoms were equal to base rate. Greater variability of heart rate change was found for allergens than for placebos (p = 0.008). Severe reactions occurred more frequently to allergens (p = 0.008). Severe reactions occurred more frequently to allergens (p = 0.02). Other dependent measures were not affected by the allergens or the placebos. It is concluded that allergens may contribute to psychopathology in some individuals.
临床生态学家报告称，接触过敏原会在易感个体中引发认知和情绪症状以及躯体症状，但对照试验却很少。在一项关于舌下接触过敏原会在过敏患者中产生认知 - 情绪症状这一假设的测试中，一家过敏诊所进行了双盲激发试验；选取了30名抱怨至少有一种心理症状的过敏患者。获取了自我报告、心率以及多项情绪和心理表现指标。明尼苏达多项人格测验（MMPI）分数表明这是一个病理性样本。报告的过敏原导致的认知 - 情绪症状比安慰剂导致的更严重（p = 0.001），而安慰剂症状与基础发生率相当。发现过敏原导致的心率变化比安慰剂导致的更具变异性（p = 0.008）。对过敏原出现严重反应的情况更频繁（p = 0.008）。对过敏原出现严重反应的情况更频繁（p = 0.02）。其他相关指标不受过敏原或安慰剂的影响。得出的结论是，过敏原可能在某些个体中导致精神病理学问题。
