[Effect of certain chemicals on DNA synthesis and distribution in human transplantable gastrointestinal tumors].

beta-Spectrophotometry and cytophotometry were used to study the effect of 8 chemopreparations on the synthesis and distribution of DNA in human strains of colonic carcinoma (CC-I and CC-II), gastric carcinoma (GC) and liver carcinoma (LC) transplanted to thymectomized mice. Irrespective of no distinct correlation between clinical manifestations of the action of chemopreparations estimated from the tumor size in mice and the number and distribution pattern of DNA, the change in the latter two parameters indicates the tumor response to the chemopreparation.