催产素商业制剂对大鼠离体输精管的假性作用。

Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat.

作者信息

Botting J H

出版信息

Br J Pharmacol. 1981 Jan;72(1):101-2. doi: 10.1111/j.1476-5381.1981.tb09111.x.

DOI:10.1111/j.1476-5381.1981.tb09111.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071552/

Abstract

1 The inhibitory effect of a commercial preparation of oxytocin (Syntocinon) was studied on the isolated vas deferens of the rat. 2 The inhibition of contractions to agonists and to field stimulation obtained were mimicked by appropriate dilutions of chlorbutol, a preservative present in Syntocinon. 3 Preservative-free synthetic oxytocin had no inhibitory effect on the tissue and slightly potentiated contractions evoked by field stimulation. 4 It is concluded that inhibitory effects of Syntocinon on the vas deferens are due to chlorbutol, not oxytocin.

摘要

1 研究了一种市售催产素制剂（缩宫素）对大鼠离体输精管的抑制作用。2 缩宫素中含有的防腐剂氯丁醇的适当稀释液可模拟其对激动剂和场刺激引起的收缩的抑制作用。3 无防腐剂的合成催产素对该组织无抑制作用，且对场刺激引起的收缩有轻微增强作用。4 得出结论，缩宫素对输精管的抑制作用是由氯丁醇引起的，而非催产素。

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