催产素对大鼠离体输精管的作用。
Effects of oxytocin on the isolated vas deferens of the rat.
作者信息
Beneit J V, Hidalgo A, Tamargo J L
出版信息
Br J Pharmacol. 1980 Jul;69(3):379-82. doi: 10.1111/j.1476-5381.1980.tb07025.x.
Abstract
1 The effect of oxytocin was studied on the isolated vas deferens of the rat. 2 Oxytocin (25 to 200 mu/ml) reversibly reduced the contractile response induced by noradrenaline, dopamine and acetylcholine. 3 Oxytocin (400 mu/ml) abolished the response to potassium. 4 The contractions evoked in the vas deferens by field stimulation were also reduced by oxytocin (50 to 200 mg/ml). The inhibitory effect of the drug was related to the external calcium concentration. 5 It is suggested that oxytocin depresses the contractile responses in the vas deferens at least partly by reducing the availability of calcium from an extracellular source.
摘要
研究了催产素对大鼠离体输精管的作用。
催产素（25至200微克/毫升）可逆性降低去甲肾上腺素、多巴胺和乙酰胆碱诱导的收缩反应。
催产素（400微克/毫升）使对钾的反应消失。
场刺激诱发的输精管收缩也被催产素（50至200微克/毫升）降低。药物的抑制作用与细胞外钙浓度有关。
提示催产素至少部分通过减少细胞外来源钙的可用性来抑制输精管的收缩反应。
相似文献
1
Effects of oxytocin on the isolated vas deferens of the rat.催产素对大鼠离体输精管的作用。
Br J Pharmacol. 1980 Jul;69(3):379-82. doi: 10.1111/j.1476-5381.1980.tb07025.x.
2
Effects of oxypertine on the isolated vas deferens of the rat.奥昔哌汀对大鼠离体输精管的作用。
Br J Pharmacol. 1978 Apr;62(4):515-8. doi: 10.1111/j.1476-5381.1978.tb07755.x.
3
Effect of 7-nitro indazole on neurotransmission in the rat vas deferens: mechanisms unrelated to inhibition of nitric oxide synthase.7-硝基吲唑对大鼠输精管神经传递的影响：与一氧化氮合酶抑制无关的机制。
Br J Pharmacol. 1994 Sep;113(1):282-8. doi: 10.1111/j.1476-5381.1994.tb16206.x.
4
The effects of cocaine and diphenhydramine upon the reactivity of rat vas deferens to supramaximal doses of noradrenaline and of other agonists: the mode of action of cocaine.可卡因和苯海拉明对大鼠输精管对去甲肾上腺素及其他激动剂超最大剂量反应性的影响：可卡因的作用方式。
Eur J Pharmacol. 1976 Feb;35(2):333-9. doi: 10.1016/0014-2999(76)90236-3.
5
Vas deferens smooth muscle responses to the nitric oxide-independent soluble guanylate cyclase stimulator BAY 41-2272.血管平滑肌肉对一氧化氮非依赖性可溶性鸟苷酸环化酶刺激剂 BAY 41-2272 的反应。
Eur J Pharmacol. 2012 Aug 5;688(1-3):49-55. doi: 10.1016/j.ejphar.2012.05.009. Epub 2012 May 22.
6
Enhancement by elevated external potassium of the maximal responses to acetylcholine and norepinephrine in the rat vas deferens.高细胞外钾增强大鼠输精管对乙酰胆碱和去甲肾上腺素的最大反应。
Eur J Pharmacol. 1979 Oct 1;58(3):321-5. doi: 10.1016/0014-2999(79)90481-3.
7
Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat.催产素商业制剂对大鼠离体输精管的假性作用。
Br J Pharmacol. 1981 Jan;72(1):101-2. doi: 10.1111/j.1476-5381.1981.tb09111.x.
8
The correlation between spontaneous contractions and postjunctional supersensitivity of the smooth muscle of the rat vas deferens.大鼠输精管平滑肌自发收缩与接头后超敏反应之间的相关性。
J Pharmacol Exp Ther. 1975 Jan;192(1):136-48.
9
Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene-related peptides (CGRP).大鼠和人降钙素基因相关肽（CGRP）对小鼠输精管收缩反应的接头后抑制作用
Br J Pharmacol. 1986 May;88(1):173-80. doi: 10.1111/j.1476-5381.1986.tb09484.x.
10
A comparison of the effect of cocaine desipramine on the contractions of the isolated vas deferens of the rat induced by dopamine and noradrenaline [proceedings].可卡因去甲丙咪嗪对多巴胺和去甲肾上腺素诱导的大鼠离体输精管收缩作用的比较[会议论文集]
West Afr J Pharmacol Drug Res. 1977 Jun;4(1):74P-75P.
引用本文的文献
1
Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists.雄性生殖管道中的催产素；催产素激动剂和拮抗剂的治疗潜力。
Front Endocrinol (Lausanne). 2020 Oct 22;11:565731. doi: 10.3389/fendo.2020.565731. eCollection 2020.
2
Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors.催产素诱导的大鼠和兔射精组织收缩是由血管加压素V1A受体介导的，而非催产素受体。
Br J Pharmacol. 2008 Sep;155(1):118-26. doi: 10.1038/bjp.2008.226. Epub 2008 Jun 16.
3
Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat.催产素商业制剂对大鼠离体输精管的假性作用。
Br J Pharmacol. 1981 Jan;72(1):101-2. doi: 10.1111/j.1476-5381.1981.tb09111.x.
本文引用的文献
1
THE INFLUENCE OF OXYTOCIN UPON SOME SEMINAL CHARACTERISTICS IN THE RABBIT.
Acta Physiol Scand. 1963 Dec;59:363-9. doi: 10.1111/j.1748-1716.1963.tb02753.x.
2
Short- and long-term effects of oxytocin on quality and quantity of semen from rams.
J Reprod Fertil. 1970 Apr;21(3):523-9. doi: 10.1530/jrf.0.0210523.
3
Effects of calcium on smooth muscles and on the adrenergic neuron blocking action of guanethidine.钙对平滑肌及胍乙啶肾上腺素能神经元阻滞作用的影响。
Arch Int Pharmacodyn Ther. 1971 Mar;190(1):34-46.
4
Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium.去除钙对去甲肾上腺素、组胺和钾诱导的血管平滑肌收缩的不同影响。
J Pharmacol Exp Ther. 1968 Jan;159(1):91-7.
5
The link between agonist action and response in smooth muscle.平滑肌中激动剂作用与反应之间的联系。
Annu Rev Pharmacol. 1971;11:303-26. doi: 10.1146/annurev.pa.11.040171.001511.
6
Dopamine receptors and dopaminergic nerves in the vas deferens of the rat.大鼠输精管中的多巴胺受体与多巴胺能神经
Arch Int Pharmacodyn Ther. 1976 Jul;222(1):4-15.
7
Effect of full agonists following calcium deprivation in rat vas deferens.钙缺乏后全激动剂对大鼠输精管的作用。
Eur J Pharmacol. 1975 Apr;31(2):292-304. doi: 10.1016/0014-2999(75)90052-7.
Zotero 插件