催产素对大鼠离体输精管的作用。
Effects of oxytocin on the isolated vas deferens of the rat.
作者信息
Beneit J V, Hidalgo A, Tamargo J L
出版信息
Br J Pharmacol. 1980 Jul;69(3):379-82. doi: 10.1111/j.1476-5381.1980.tb07025.x.
Abstract
1 The effect of oxytocin was studied on the isolated vas deferens of the rat. 2 Oxytocin (25 to 200 mu/ml) reversibly reduced the contractile response induced by noradrenaline, dopamine and acetylcholine. 3 Oxytocin (400 mu/ml) abolished the response to potassium. 4 The contractions evoked in the vas deferens by field stimulation were also reduced by oxytocin (50 to 200 mg/ml). The inhibitory effect of the drug was related to the external calcium concentration. 5 It is suggested that oxytocin depresses the contractile responses in the vas deferens at least partly by reducing the availability of calcium from an extracellular source.
摘要
研究了催产素对大鼠离体输精管的作用。
催产素（25至200微克/毫升）可逆性降低去甲肾上腺素、多巴胺和乙酰胆碱诱导的收缩反应。
催产素（400微克/毫升）使对钾的反应消失。
场刺激诱发的输精管收缩也被催产素（50至200微克/毫升）降低。药物的抑制作用与细胞外钙浓度有关。
提示催产素至少部分通过减少细胞外来源钙的可用性来抑制输精管的收缩反应。
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本文引用的文献
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THE INFLUENCE OF OXYTOCIN UPON SOME SEMINAL CHARACTERISTICS IN THE RABBIT.
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Short- and long-term effects of oxytocin on quality and quantity of semen from rams.
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Effects of calcium on smooth muscles and on the adrenergic neuron blocking action of guanethidine.
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Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium.去除钙对去甲肾上腺素、组胺和钾诱导的血管平滑肌收缩的不同影响。
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The link between agonist action and response in smooth muscle.平滑肌中激动剂作用与反应之间的联系。
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Dopamine receptors and dopaminergic nerves in the vas deferens of the rat.大鼠输精管中的多巴胺受体与多巴胺能神经
Arch Int Pharmacodyn Ther. 1976 Jul;222(1):4-15.
7
Effect of full agonists following calcium deprivation in rat vas deferens.钙缺乏后全激动剂对大鼠输精管的作用。
Eur J Pharmacol. 1975 Apr;31(2):292-304. doi: 10.1016/0014-2999(75)90052-7.
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