Keith R G, Sheppard R H, Saibil F G, Brow J R
Can J Surg. 1981 Mar;24(2):119-24.
Nineteen patients with chronic alcoholic pancreatitis have been followed up for 7 to 81 months (mean 45 months) since resection for the relief of pain. Five had distal pancreatectomy, three had a Whipple resection, seven had 75% pancreatectomy and four had total pancreatectomy. Pain was completely relieved in all patients after total pancreatectomy and in four patients after 75% pancreatectomy. Recurrent acute pancreatitis was frequent after distal pancreatectomy. Alcoholism recurred in six patients. Steatorrhea was noted grossly in 14 patients after operation. It was corrected by enzyme replacement. All patients had long-term weight gain, except one who had undergone a Whipple resection. Diabetes developed in one patient who underwent 75% pancreatectomy, in one after distal pancreatectomy and in all patients who underwent total pancreatectomy; management of the diabetes was complicated by heavy alcohol consumption in one patient who underwent total pancreatectomy.
19例慢性酒精性胰腺炎患者因疼痛缓解接受切除术后,随访了7至81个月(平均45个月)。5例行胰体尾切除术,3例行惠普尔手术,7例行75%胰腺切除术,4例行全胰切除术。全胰切除术后所有患者疼痛完全缓解,75%胰腺切除术后4例患者疼痛完全缓解。胰体尾切除术后复发性急性胰腺炎很常见。6例患者酗酒复发。术后14例患者出现明显脂肪泻,通过酶替代治疗得以纠正。除1例接受惠普尔手术的患者外,所有患者体重均长期增加。1例接受75%胰腺切除术的患者、1例胰体尾切除术后患者以及所有接受全胰切除术的患者均发生糖尿病;1例接受全胰切除术的患者因大量饮酒使糖尿病管理变得复杂。