Jereb B, Sundaresan N, Horten B, Reid A, Galicich J H
Cancer. 1981 Feb 15;47(4):806-9. doi: 10.1002/1097-0142(19810215)47:4<806::aid-cncr2820470429>3.0.co;2-p.
Four children with medulloblastoma had massive supratentorial recurrences in the region of the cribriform plate after adequate craniospinal irradiation. The pathogenesis of these recurrences is probably related to underdosage to this region by shielding of the eyes. This hypothesis was corroborated by autopsy findings in two other patients in whom subfrontal implants were histologically different from recurrences elsewhere. Two possible solutions to avoid this problem in the future are suggested.
四名髓母细胞瘤患儿在接受充分的全脑全脊髓照射后，在筛板区域出现大量幕上复发。这些复发的发病机制可能与眼部屏蔽导致该区域剂量不足有关。另外两名患者的尸检结果证实了这一假设，这两名患者的额下植入物在组织学上与其他部位的复发不同。文中提出了未来避免这一问题的两种可能解决方案。
