Schipper H, Decter A
Cancer. 1981 Apr 15;47(8):2062-5. doi: 10.1002/1097-0142(19810415)47:8<2062::aid-cncr2820470826>3.0.co;2-9.
Colon carcinomas develop at the site of implantation in approximately 6% of patients who undergo ureterosigmoidostomy for benign conditions. Generally, the obstruction of a long-functioning ureterosigmoidostomy heralds the presentation of the malignancy. The development of a carcinoma of the colon at the site of the ureteral stump 22 years after conversion to ileal conduit in a ureterosigmoidostomy, which had been in place for only nine months, raises fundamental questions about the pathogenesis of the tumor. The long-assumed role of urine in the induction of these iatrogenic tumors must be questioned. This issue and suggestions for management and prevention are discussed.
在因良性疾病接受输尿管乙状结肠吻合术的患者中，约6%会在植入部位发生结肠癌。一般来说，长期发挥功能的输尿管乙状结肠吻合术出现梗阻预示着恶性肿瘤的出现。一例输尿管乙状结肠吻合术在转换为回肠导管22年后，在输尿管残端部位发生结肠癌，而该输尿管乙状结肠吻合术仅使用了9个月，这引发了关于肿瘤发病机制的基本问题。长期以来认为尿液在这些医源性肿瘤诱导中所起的作用必须受到质疑。本文讨论了这个问题以及管理和预防建议。
