Puri V K, Schaeffer R C, Carlson R W, Weil M H
Circ Shock. 1980;7(4):447-56.
A model of regional shock is described to study the dynamics of lactacidemia which accompanies perfusion failure. The suprarenal abdominal aorta was occluded with a balloon catheter to reduce the mean perfusion pressure to 25 mmHg in 5 dogs each for 60 and 120 minutes, while 5 dogs served as controls. Increases in arterial lactate from 2.4 r - 1.1 to 4.9 r - 1.2 mM/L were observed by 60 minutes. Lactate concentrations sampled from arterial and venous sites proximal and distal to the obstruction, showed good correlation (r=0.96) during and for 240 minutes following deflation of aortic balloon. Lactate clearance in experimental animals was accomplished by 90 minutes of re-establishment of flow to the lower extremities. Hemodynamic changes included tachycardia, upper body hypertension, with any increase in left ventricular filling pressures. Marked hemoconcentration observed in experimental animals was suggestive of plasma losses in splanchnic circulation, confirmed by autopsy findings of bowel edema and infraction, In this model of regional shock, absence of true lactate "washout" was also confirmed.
描述了一种局部休克模型，以研究伴随灌注衰竭的乳酸血症的动态变化。用球囊导管阻断5只狗的肾上腹主动脉，使平均灌注压降至25 mmHg，分别持续60分钟和120分钟，同时5只狗作为对照。60分钟时观察到动脉乳酸从2.4±1.1 mM/L增加到4.9±1.2 mM/L。在主动脉球囊放气期间及之后240分钟内，从梗阻近端和远端的动脉和静脉部位采集的乳酸浓度显示出良好的相关性（r = 0.96）。实验动物的乳酸清除在下肢血流重新建立90分钟后完成。血流动力学变化包括心动过速、上身高血压以及左心室充盈压的任何升高。实验动物中观察到的明显血液浓缩提示内脏循环中有血浆丢失，尸检发现肠水肿和梗死证实了这一点。在这种局部休克模型中，也证实了不存在真正的乳酸“清除”。
