Ferguson J L, Hikawyj-Yevich I, Miller H I
Circ Shock. 1980;7(4):457-66.
The alterations in body fluid compartments 1, 4, and 8 hours after a 70% full-skin thickness burn were studied in conscious guinea pigs. Concurrently, we measured hemodynamic changes associated with the burn. Cardiac output and heart rate were depressed one hour postburn, and mean arterial blood pressure was depressed eight hours postburn. A hemoconcentration one-hour postburn, as evidence by an increase in hematocrit, was due exclusively to a loss of plasma volume. Red blood cell (RBC) volume remained constant after the burn. As a consequence of decreased plasma volume, total blood volume was also depressed. Extracellular fluid was decreased on hour after the burn; how ever, four and eight hours postburn, extracellular fluid space was comparable to that in the control group. Total body water and body weights of burned animals did not differ from control values. This study has demonstrated the very rapid redistribution of fluids in burn shock without a loss of fluids from the body.
在清醒的豚鼠身上研究了70%全层皮肤烧伤后1小时、4小时和8小时体液腔室的变化。同时，我们测量了与烧伤相关的血流动力学变化。烧伤后1小时心输出量和心率降低，烧伤后8小时平均动脉血压降低。烧伤后1小时出现血液浓缩，表现为血细胞比容升高，这完全是由于血浆量减少所致。烧伤后红细胞（RBC）体积保持不变。由于血浆量减少，总血容量也降低。烧伤后1小时细胞外液减少；然而，烧伤后4小时和8小时，细胞外液间隙与对照组相当。烧伤动物的总体水和体重与对照值无差异。这项研究表明，烧伤休克时体液会非常迅速地重新分布，而身体并未丢失体液。
