Towell M E, Lysak I, Layne E C, Sayler D, Bessman S P
Circ Shock. 1981;8(2):123-30.
Tissue PO2 in the rabbit was measured with galvanic oxygen electrodes chronically implanted in peritoneal and subcutaneous tissues; blood PO2 was measured in arterial and venous blood samples obtained from chronically implanted catheters. The effect of intravenous epinephrine 4 microgram/kg on tissue and blood PO2 was examined in the unanesthetized animal. Basal tissue PO2 values were 43.6 +/- 1.71 mm Hg (mean +/- SEM) for peritoneum and 15.9 +/- 2.51 mm Hg for subcutaneous tissue. These values increased to 112.8 +/- 8.67 mm Hg (peritoneum) and 76.0 +/- 2.24 mm Hg (subcutaneous) after 15 minutes of O2 breathing. Epinephrine led to significant reductions in tissue PO2 during both air and O2 breathing without affecting blood PO2. It is concluded that epinephrine administration alters the relationship between blood and tissue PO2 leading to relative tissue hypoxia despite normal or high blood PO2. These observations are important to an understanding of shock and emphasize the need for further investigation of tissue PO2 as a measure of shock states.
采用长期植入兔腹膜和皮下组织的电流型氧电极测量兔组织的氧分压（PO₂）；通过从长期植入的导管采集的动脉血和静脉血样本测量血液PO₂。在未麻醉的动物中，研究了静脉注射4微克/千克肾上腺素对组织和血液PO₂的影响。腹膜的基础组织PO₂值为43.6±1.71毫米汞柱（平均值±标准误），皮下组织为15.9±2.51毫米汞柱。吸氧15分钟后，这些值分别升至112.8±8.67毫米汞柱（腹膜）和76.0±2.24毫米汞柱（皮下）。肾上腺素导致在空气呼吸和吸氧过程中组织PO₂显著降低，而不影响血液PO₂。得出的结论是，给予肾上腺素会改变血液和组织PO₂之间的关系，导致尽管血液PO₂正常或升高，但仍出现相对的组织缺氧。这些观察结果对于理解休克很重要，并强调有必要进一步研究将组织PO₂作为休克状态的一种衡量指标。
