Mehmel H C, Stockins B, Ruffmann K, von Olshausen K, Schuler G, Kübler W
Circulation. 1981 Jun;63(6):1216-22. doi: 10.1161/01.cir.63.6.1216.
The linearity and sensitivity of the end-systolic pressure-volume (P-Ves) relation to the inotropic state of the left ventricle were investigated in 11 patients with coronary heart disease and one patient with congestive cardiomyopathy. To minimize autonomic reflex responses, propranolol, 0.15 mg/kg, and atropine, 1 mg, were administered i.v. at the beginning of the study. Three ventriculograms were performed: at rest, after oral isosorbide dinitrate, 10 mg (systolic pressure decrease greater than or equal to 15 mm Hg), and during infusion of methoxamine, 2 mg/min (systolic pressure increase greater than or equal to 10 mm Hg). The three points of the Pv-Ves relation showed linearity (r greater than or equal to 0.96). The relation between the slope k of the P-Ves relation and the left ventricular ejection fraction at rest was best described by an exponential function (r = 0.94). The use of peak systolic pressure instead of end-systolic pressure showed equally good results. The intercept of the P-Ves line on the abscissa, which represents the theoretical end-systolic volume at zero pressure, was not related to the ejection fraction under control conditions. The P-Ves relation in postextrasystolic beats was displaced toward the left (smaller end-systolic volumes) and became steeper.
在11例冠心病患者和1例充血性心肌病患者中，研究了收缩末期压力-容积（P-Ves）关系对左心室变力状态的线性和敏感性。为了尽量减少自主反射反应，在研究开始时静脉注射0.15mg/kg普萘洛尔和1mg阿托品。进行了三次心室造影：静息时、口服10mg硝酸异山梨酯后（收缩压降低大于或等于15mmHg）以及静脉输注甲氧明期间（收缩压升高大于或等于10mmHg）。Pv-Ves关系的三个点呈线性（r大于或等于0.96）。P-Ves关系的斜率k与静息时左心室射血分数之间的关系最好用指数函数描述（r = 0.94）。使用收缩压峰值而非收缩末期压力显示出同样良好的结果。P-Ves线在横坐标上的截距，代表零压力下的理论收缩末期容积，在对照条件下与射血分数无关。早搏后的P-Ves关系向左移位（收缩末期容积较小）且变得更陡峭。
