原卟啉对大鼠肝脏线粒体和溶酶体的光损伤。
Protoporphyrin-induced photodamage to mitochondria and lysosomes from rat liver.
作者信息
Sandberg S
出版信息
Clin Chim Acta. 1981 Mar 19;111(1):55-60. doi: 10.1016/0009-8981(81)90420-4.
PMID:7226541
Abstract
Preparations of mitochondria and lysosomes from rat liver were irradiated (340--380 nm) with light doses up to 80 kJ/m2 in the presence of 180 nmol/l protoporphyrin. ADP-stimulated respiration and succinate oxidation were inhibited before there was any significant release or inhibition of lysosomal enzymes. The results suggest that, rather than lysosomal lysis, damage to mitochondria may be the primary event in erythropoietic protoporphyria.
摘要
在180纳摩尔/升原卟啉存在的情况下，用高达80千焦/平方米的光剂量（340 - 380纳米）照射大鼠肝脏的线粒体和溶酶体制剂。在溶酶体酶有任何显著释放或抑制之前，ADP刺激的呼吸和琥珀酸氧化就受到了抑制。结果表明，在红细胞生成性原卟啉症中，线粒体损伤而非溶酶体裂解可能是主要事件。
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