Curradi F, Abbritti G, Agnelli G
Clin Toxicol. 1981 Feb;18(2):221-4. doi: 10.3109/15563658108990028.
We report a case of severe thrombocytopenia following oral cholecystography with iopanoic acid, a widely used contrast medium. A bone marrow aspirate showed increased numbers of megakaryocytes, suggesting a thrombocytopenia due to enhanced peripheral destruction of platelets; this examination was not reported in the previously described two cases. Although hematological reactions due to iopanoic acid are very rare, it would be wise to question patients regarding any preceding drug-induced purpura before proceeding with oral cholecystography.
我们报告一例在使用广泛应用的造影剂碘番酸进行口服胆囊造影术后出现严重血小板减少症的病例。骨髓穿刺显示巨核细胞数量增加，提示血小板减少是由于外周血小板破坏增强所致；此前描述的两例病例未报告此项检查结果。尽管碘番酸引起的血液学反应非常罕见，但在进行口服胆囊造影术前询问患者是否有先前药物性紫癜病史是明智的。
