潜在的抗癌剂。16. 具有修饰肽侧链的甲氨蝶呤类似物。
Potential anticancer agents. 16. Methotrexate analogues with a modified peptide side chain.
作者信息
Suster D C, Tărnăuceanu E, Ionescu D, Dobre V, Niculescu-Duvăz I
出版信息
J Med Chem. 1978 Nov;21(11):1162-5. doi: 10.1021/jm00209a015.
PMID:722722
Abstract
Nine analogues of methotrexate, in which the side chain is modified by replacement of the terminal glutamyl moiety with other amino acids, were synthesized from 2,4-diamino-6-(chloromethyl)pteridine. None of these compounds exhibited significant activity against L1210.
摘要
从2,4-二氨基-6-(氯甲基)蝶啶合成了9种甲氨蝶呤类似物，其中侧链通过用其他氨基酸取代末端谷氨酰部分进行了修饰。这些化合物均未表现出对L1210的显著活性。
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