Aromatic hydroxylation of beta-adrenergic antagonists. 4- and 5-hydroxylation of 1-(isopropylamino)-3-[2-(allyloxy)phenoxy]-2-propanol (oxprenolol).
作者信息
Nelson W L, Burke T R
出版信息
J Med Chem. 1978 Dec;21(12):1185-6. doi: 10.1021/jm00210a001.
PMID:722725
Abstract
摘要
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1
Aromatic hydroxylation of beta-adrenergic antagonists. 4- and 5-hydroxylation of 1-(isopropylamino)-3-[2-(allyloxy)phenoxy]-2-propanol (oxprenolol).β-肾上腺素能拮抗剂的芳香羟基化。1-(异丙氨基)-3-[2-(烯丙氧基)苯氧基]-2-丙醇（氧烯洛尔）的4-和5-羟基化反应。
J Med Chem. 1978 Dec;21(12):1185-6. doi: 10.1021/jm00210a001.
2
Aromatic hydroxylation of beta-adrenergic antagonists. Formation of 4'- and 5'-hydroxy-1-(isopropylamino)-3-[2'-allyloxy)phenoxy]-2-propanol from oxprenolol.β-肾上腺素能拮抗剂的芳香族羟基化反应。从氧烯洛尔生成4'-和5'-羟基-1-(异丙氨基)-3-[2'-烯丙氧基)苯氧基]-2-丙醇。
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3
Metabolism of beta-adrenergic antagonists. Evidence for an arene oxide-NIH shift pathway in the aromatic hydroxylation of oxprenolol.
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4
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