Maguire J H, Butler T C, Dudley K H
J Med Chem. 1978 Dec;21(12):1294-7. doi: 10.1021/jm00210a023.
5-(3-Hydroxyphenyl)-5-phenylhydantoin (m-HPPH) has been resolved by crystallization of the brucine salts. The (+) enantiomer has been converted to (-)-5-cyclohexyl-5-phenylhydantoin, a compound previously demonstrated to have the R configuration. The R configuration can accordingly be assigned to (+)-m-HPPH, the principal metabolite of 5,5-diphenylhydantoin (phenytoin) in the dog.
5-(3-羟基苯基)-5-苯基乙内酰脲（间羟基苯妥英，m-HPPH）已通过马钱子碱盐的结晶进行拆分。(+)对映体已被转化为(-)-5-环己基-5-苯基乙内酰脲，该化合物先前已证明具有R构型。因此，R构型可指定给(+)-m-HPPH，它是犬体内5,5-二苯基乙内酰脲（苯妥英）的主要代谢产物。
