Iijima I, Minamikawa J, Rice K C, Jacobson A E
J Med Chem. 1978 Dec;21(12):1320-2. doi: 10.1021/jm00210a031.
(-)-7-Methoxycodeine was synthesized from (-)-1-bromosinomeninone in three steps with an overall yield of 29%. The introduction of the 7-methoxy group into the C ring of codeine did not decrease its oral activity. 7-Methoxycodeine was unstable in acidic media. Its oral activity was however, not likely to be due to conversion to the acid-stable (-)-sinomeninone, since the latter was orally inactive.
（-）-7-甲氧基可待因由（-）-1-溴青藤碱酮经三步合成，总产率为29%。将7-甲氧基引入可待因的C环并未降低其口服活性。7-甲氧基可待因在酸性介质中不稳定。然而，其口服活性不太可能是由于转化为酸稳定的（-）-青藤碱酮，因为后者口服无活性。
