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3-甲酰基哒嗪-2-氧化物和4-甲酰基嘧啶-3-氧化物的芳基磺酰腙的抗肿瘤特性

Antineoplastic properties of arylsulfonylhdrazones of 3-formylpyridazine 2-oxide and 4-formylpyrimidine 3-oxide.

作者信息

May J A, Sartorelli A C

出版信息

J Med Chem. 1978 Dec;21(12):1333-5. doi: 10.1021/jm00210a036.

DOI:10.1021/jm00210a036
PMID:722747
Abstract

The antineoplastic activity of several arylsulfonylhydrazones of 4-formylpyrimidine 3-oxide and of 3-formylpyridazine 2-oxide has been investigated. Derivatives of the latter heteroaromatic N-oxide showed excellent antineoplastic potency against the murine neoplasm Sarcoma 180 but were inactive against leukemia L1210. In contrast, derivatives of 4-formylpyrimidine 3-oxide were inactive against both of these transplanted tumors.

摘要

已对几种4-甲酰基嘧啶3-氧化物和3-甲酰基哒嗪2-氧化物的芳基磺酰腙的抗肿瘤活性进行了研究。后一种杂芳族N-氧化物的衍生物对小鼠肿瘤肉瘤180显示出优异的抗肿瘤效力，但对白血病L1210无活性。相比之下，4-甲酰基嘧啶3-氧化物的衍生物对这两种移植肿瘤均无活性。

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